Anadrol is the strongest anabolic steroid known today (in terms of its anabolic effects) but also one of the most dangerous to use. Except perhaps Halotestin (fluoxymesterone), there is hardly any more liver toxic steroid on the market. Anadrol should therefore be used with great care, if at all. That said, let’s admit that the muscle mass gains with Anadrol are huge, although not easiest to maintain and esthetically not very appealing. The reason is considerable fat and water retention caused by estrogenic effects of this drug. This is true despite the fact that anadrol practically does not aromatize. The likely explanation is that Anadrol itself activates the estrogen receptor, which is not unlikely considering the form of the molecule (having a similar ring estradiol). It is quite obvious that anti-estrogenic ancillary medication is often used in conjunction with this drug, but one must remember that a significant part of its effects are mediated by estrogen receptor activation, which means that the anti-estrogens can also reduce earnings mass by Anadrol.